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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jan 14;36(3):510–517. doi: 10.1161/ATVBAHA.115.307034

Figure 5. FXIa activity promotes distal platelet activation and consumption in the presence of collagen and low levels of TF.

Figure 5

Recalcified whole blood pretreated with either vehicle, 1A6, 14E11, 10C9, CTI or hirudin was perfused over chambers coated with collagen, collagen + 0.01 – 0.1 nM TF, or 0.01 – 0.1 nM TF alone at shear rate of 300 s−1. Samples were collected downstream of the chamber; distal microaggregate formation and single platelet consumption was assessed by FACS (A–E). Results (mean±SEM) from at least 4 experiments.