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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Arthritis Rheumatol. 2016 Mar;68(3):724–729. doi: 10.1002/art.39497

Figure 1. Anti-TRIM38 autoantibody levels in pSjS patients and their association with clinical measures of dry eye and dry mouth.

Figure 1

Top panel: Sera from 235 pSjS patients and 50 verified controls were tested for reactivity with in vitro transcribed, translated, and 35S-Met labeled TRIM38. Data are shown as antibody units based on a positive control pool from anti-TRIM38 positive lupus patients. The dotted line shows the cut-off for positivity, based on Mean+2SD of verified control sera. All samples above the cut-off were considered positive. Based on the reactivity with TRIM38, the pSjS population was split into 2 groups, anti-TRIM38+ (n=24) and anti-TRIM38− (n=211) and clinical measurements for dry eye (middle panel: vB score, Schirmer’s test scores) and dry mouth (bottom panel: minor labial salivary gland focus score and WUSF) were compared between these 2 groups. Statistical significance was determined by the Mann-Whitney test.