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HOdU-modified deoxyribozymes for amide hydrolysis. (A) Sequence of the initially random (N40) regions of AmideHy1, 2, and 3. Each blue T is HOdU in the deoxyribozyme. (B) PAGE assay (t = 0, 48 h). (C) Kinetic plots. kobs, h−1 (n = 3): AmideHy1 mod 0.089 ± 0.011 and unmod 0.034 ± 0.003; AmideHy2 0.084 ±0.004; AmideHy3 0.17 ± 0.02. (D) Mass spectrometry analysis of products (similar for AmideHy2,3; not shown).
