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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Nat Genet. 2016 Feb 1;48(3):273–282. doi: 10.1038/ng.3500

Figure 2. Alterations of MYB and QKI occur frequently in human cancers.

Figure 2

a. MYB expression (mean ± SEM) in normal human colon (n=12), breast (n=27), whole blood (n=51), esophagus (n=38), skin (n=25), and brain cortex (n=47).

b. MYB immunohistochemistry on human adult frontal cortex. Scale bar = 100 microns

c. MYB immunohistochemistry on human adult white matter. Scale bar = 100 microns

d. Hematoxylin and eosin (H&E) on human fetal neural stem cells generated from the ganglionic eminence at 22 weeks gestation. Scale bar = 100 microns

e. MYB immunohistochemistry demonstrates positive staining in a subset of cells. Scale bar = 100 microns

f. Sagittal section from embryonic 14.5 days post coitus (E14.5) mouse brain. Scale bar = 500 microns.

g. H&E of E14.5 ganglionic eminence (ge) including ventricular (ge-vz) and subventricular (ge-svz) zones. Scale bar = 50 microns.

h. MYB immunohistochemistry on the E14.5 ganglionic eminence. Scale bar = 50 microns.

i. MYB immunohistochemistry demonstrates positive staining in subventricular zone (ge-svz) but not the ventricular zone (ge-vz). Scale bars = 50 microns.

j. H&E from periventricular region of adult mouse brain. Scale bar = 100 microns.

k. Immunohistochemistry for MYB demonstrates positive cells (arrows) in the ependymal/SVZ layer. Scale bars = 100 microns.

l. (Left) Significance of deletions (x-axis) and (middle and right) heatmaps indicating copy-number profiles at 6q of individual adult Glioblastomas.

m. Structure of the MYB-QKI fusion protein. TAD denotes transactivating domain. C-terminus of QKI includes QUA2 domains. MYB-QKI5 retains a nuclear localizing sequence (NLS). Two variants of MYB-QKI are depicted corresponding to the breakpoint of MYB.