Figure 7. MYB-QKI disrupts expression of QKI, a tumor suppressor gene.
a. Exon specific expression of in Angiocentric Gliomas (n=5) relative to BRAF-driven PLGGs (n=5). Values represent mean ± SEM. RNA-sequencing data of Exon 8 of QKI revealed a high number of duplicate reads and thus is not shown.
b. Cell proliferation of mouse neural stem cells expressing MYBtr, MYB-QKI5, MYB-QKI6 or eGFP control with suppression of wild-type Qk. Values represent mean of four independent experiments ± SEM.
c. Expression of signature within each tumor is the sum of rpkm of each gene in the signature.