Table 3.
Ag in gastrointestinal tract (stomach, cecum, esophagus and intestines) at 48 h after oral gavage with 10 mg/kg AgNP or AgOAc.a
| Dosing group | Vehicle (coating) | Ag dose (mg/kg) | Ag in GI tract (μg/g)
|
Ag in GI tract (% recovery of administered dose)
|
||
|---|---|---|---|---|---|---|
| Meana | SD | Meana | SD | |||
| AgNP 20 nm | 2 mM citrate | 10 | 0.030 | 0.029 | 0.05 | 0.05 |
| AgNP 110 nm | 2 mM citrate | 10 | 0.015 | 0.008 | 0.02 | 0.01 |
| AgNP 20 nm | 10 kDa PVP | 10 | 0.032 | 0.026 | 0.04 | 0.04 |
| AgNP 110 nm | 40 kDa PVP | 10 | 0.152 | 0.257 | 0.21 | 0.34 |
| AgOAc | Sterile H2O | 10 | 0.177 | 0.153 | 0.27 | 0.24 |
| na | 2 mM citrate | 0 | 0.002 | 0.000 | na | na |
| na | 10 kDa PVP | 0 | 0.002 | 0.001 | na | na |
| na | 40 kDa PVP | 0 | 0.002 | 0.001 | na | na |
| na | Sterile H2O | 0 | 0.002 | 0.001 | na | na |
a
No significant differences between the Ag-dosed groups (one-way ANOVA, Tukey’s multiple comparison’s test, significance p<0.05).