. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Nanotoxicology. 2015 Aug 24;10(3):352–360. doi: 10.3109/17435390.2015.1072588

Table 4.

Ag in tissues (liver, spleen and kidney) at 48 h after oral gavage with 10 mg/kg bw/d AgNP or AgOAc.^a

Dosing group	Vehicle (coating)	Ag dose (mg/kg)	Ag in liver (ng/g)^b		Ag in liver (% recovery administered dose)		Ag in spleen (ng/g)^b		Ag in spleen (% recovery administered dose)		Ag in kidney (ng/g)^b		Ag in kidney (% recovery administered dose)
Dosing group	Vehicle (coating)	Ag dose (mg/kg)	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean^a	SD
AgNP 20 nm	2 mM citrate	10	16.87	11.43	0.008	0.005	22.94	9.78	0.0110	0.0050	2.62	0.81	0.0010	0.0003
AgNP 110 nm	2 mM citrate	10	11.19	7.45	0.005	0.003	24.45	11.13	0.0114	0.0053	2.12	0.20	0.0010	0.0001
AgNP 20 nm	10 kDa PVP	10	12.88	4.83	0.006	0.002	26.44	9.34	0.0128	0.0045	2.21	0.14	0.0011	0.0001
AgNP 110 nm	40 kDa PVP	10	8.11	6.65	0.004	0.003	33.17	18.11	0.0164	0.0091	2.43	0.20	0.0012	0.0001
AgOAc	sterile H₂O	10	301.32^‡‡‡	162.50	0.144^‡‡‡	0.810	94.44^‡‡	60.37	0.045^‡	0.029	12.54^‡‡‡	6.77	0.0060^‡‡‡	0.0034
na	2 mM citrate	0	1.04	0.03	na	na	15.34	0.45	na	na	2.23	0.23	na	na
na	10 kDa PVP	0	0.98	0.07	na	na	22.78	9.92	na	na	2.28	0.40	na	na
na	40 kDa PVP	0	1.00	0.06	na	na	12.33	6.87	na	na	2.22	0.30	na	na
na	sterile H₂O	0	0.92	0.09	na	na	22.94	11.46	na	na	2.17	0.17	na	na

Significantly different from AgNP groups

^‡‡‡

p<0.0001,

^‡‡

p = 0.002,

^‡

p = 0.003; one-way ANOVA, Tukey’s multiple comparisons test.

Note that mass recovery of Ag is expressed in ng/g tissue.