Dimethyl trisulfide (DMTS) is a lead candidate cyanide countermeasures that is safe for consumption and has demonstrated good efficacy against cyanide poisoning in several animal models.

We performed a stability study of a 15 % polysorbate 80-DMTS formulation and found that a reduction in concentration of DMTS in the formulation (e.g., 36–58 % over the course of 29 weeks when stored at room temperature) could not be explained by formulation storag temperature, preparative laboratory, or formulation pH.

Based on various other analytical techniques performed, we suggest that the instability of the formulation is governed at least partially by precipitation and evaporation, although a combination of factors is likely involved.