Fig. 1.

Normetanephrine (nmol/L) (a); C-terminal cross-linking telopeptides of collagen type I (CTx) (ng/L), a marker for bone resorption (b); and procollagen type 1 N propeptide (P1NP) (μg/L), a marker for bone formation (c) on the control (open dots) and intervention (closed dots) time points. Normetanephrine concentrations declined after clonidine treatment (time*intervention effect, p < 0.001). CTx was higher after clonidine compared to control (time*intervention effect, p = 0.035). P1NP concentrations were not affected by clonidine (time*intervention effect, p = 0.520). Data are expressed as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001