Skip to main content
. 2015 Sep 7;4(9):e167. doi: 10.1038/oncsis.2015.26

Figure 5.

Figure 5

Overexpression of wild-type FOXK2 sensitizes MCF-7 cells to paclitaxel treatment. (a) MCF-7 and MCF-7TaxR cells were transfected with the empty vector (pCMV5) and the wild-type FOXK2 vector, seeded in 96-well plates and treated with increasing concentrations of paclitaxel. After 24, 48 and 72 h of incubation with the drugs, cell viability was assessed by SRB assay. (b) MCF-7 and MCF-7TaxR were transfected with the empty vector (pCMV5) and the wild-type FOXK2 vector, seeded in six-well plates and treated with increasing concentrations of paclitaxel. After 48 h of incubation with the drugs, cells were cultured in fresh media, grown for around 14 days and stained with crystal violet. The graphs are representative of three experiments. Statistical significance was determined by Student's t-test (two-sided; *P⩽0.05, **P⩽0.01, ***P⩽0.001, significant).