TABLE 1.
MICs obtained in tests with E. cloacae G6809 isolate (blaKPC-18 and blaVIM-1 positive) and its blaVIM-1-positive transformant
| Drug | MICa with: |
||
|---|---|---|---|
| E. cloacae G6809 | E. coli TOP10 (pG6809-2) | E. coli TOP10 | |
| Ticarcillin-clavulanic acid | >128/2 | >128/2 | ≤16/2 |
| Piperacillin-tazobactam | >64/4 | >64/4 | ≤8/4 |
| Cefotaxime | >32 | 32 | ≤1 |
| Ceftazidime | >16 | >16 | ≤1 |
| Cefepime | >16 | 8 | ≤2 |
| Aztreonam | >16 | ≤2 | ≤2 |
| Ertapenem | 1.5 | 0.19 | 0.004 |
| Imipenem | 3 | 2 | 0.38 |
| Meropenem | 0.75 | 0.5 | 0.032 |
| Ceftazidime-avibactam | >256/4 | >256/4 | 0.25/4 |
| Aztreonam-avibactam | 0.5/4 | ≤0.06/4 | ≤0.06/4 |
| Gentamicin | ≤1 | ≤1 | ≤1 |
| Tobramycin | 8 | 8 | ≤1 |
| Amikacin | 8 | 8 | ≤4 |
| Levofloxacin | >8 | ≤1 | ≤1 |
| Ciprofloxacin | >2 | ≤1 | ≤1 |
| Trimethoprim-sulfamethoxazole | >4/76 | 2/38 | ≤0.5/9.5 |
| Minocycline | 8 | ≤2 | ≤2 |
| Doxycycline | 8 | ≤2 | ≤2 |
| Tigecycline | 0.5 | ≤0.25 | ≤0.25 |
| Polymyxin B | ≤0.25 | ≤0.25 | ≤0.25 |
| Colistin | ≤0.25 | ≤0.25 | ≤0.25 |
a
The MICs were obtained with broth microdilution (Sensititre GNX2F), except for the carbapenems and ceftazidime-avibactam, which were obtained with Etest, and aztreonam-avibactam, which were obtained with standard broth microdilution.