TABLE 2.
Time and cost parametersa
| Parameter | Mean value (reference[s]) | 95% CI | γ distribution |
|---|---|---|---|
| LOS (days) | |||
| Avg | 21 (18–20) | 16.9–29 | 16.5 + f(6.33, 0.632) |
| Reduction in LOS due to early treatment | 5.5 (4, 18) | 0.3– 13.7 | f(1.494, 2.945) |
| Duration of treatment (days) | |||
| Infected patients | 16.5 (6, 21, 22) | 15–18.7 | 14 + f(6.925, 0.361) |
| Noninfected subjects | 5 | ||
| Reduction in duration of therapy due to early treatment | 1 (40) | 0.3–2.2 | f(2.838, 1.938) |
| Time to blood culture identification of species (days) | |||
| C. albicans | 1.8 (41–44) | 0.8–2.7 | f(11.111, 0.144) |
| C. tropicalis | 1.2 (41–44) | 0.2–2.6 | f(2.367, 0.423) |
| C. parapsilosis | 2.9 (41–44) | 0.5–3.0 | f(5.165, 0.29) |
| C. glabrata | 4.1 (41–44) | 1.0–5.8 | f(5.297, 0.547) |
| C. krusei | 1.2(41–44) | 0.03–3.2 | f(1.095, 0.822) |
| Time to negative culture result (days) | 5 | ||
| Time to susceptibility results after ID (days) | 1.9 | 1.1–2.9 | f(17.827, 0.107) |
| Costs ($)b | |||
| Non-ICU (per day) | 1,500 (28) | 857–2,319 | f(16, 93.75) |
| ICU (per day) | 3,300 (18, 28) | 1,886–5,103 | f(16, 206.25) |
| Fluconazole (per day) | 5.4 (29) | 3.10–8.40 | f(16, 0.34) |
| Echinocandins (per day) | 76 | 43–118 | f(16, 4.75) |
| T2Candida test (per test) | 265 | 151–410 | f(16, 16) |
| Rapid species identification (per test) | 129 |
a
All time and cost variables were defined by gamma distributions.
b
A standard deviation of 25% was assumed for all costs.