TABLE 3.

Efficacy of compounds tested as a percentage of total number of clinical isolates inhibited in multiple assays

Bacterial species	% efficacy by treatment for:
	Disrupting a preformed biofilm				Bacterial killing within a preformed biofilm				Killing bacteria shed from a biofilm during treatment challenge
	NAC	H2O2	Tris-EDTA	THAM-EDTA	NAC	H2O2	Tris-EDTA	THAM-EDTA	NAC	H2O2	Tris-EDTA	THAM-EDTA
E. coli	70	90	40	10	100	100	80	0	100	100	100	100
K. pneumoniae	0	0	10	0	100	100	0	0	100	100	100	100
P. aeruginosa	30	40	10	0	100	20	0	0	100	100	100	100

^aAgents were 3.3% N-acetylcysteine (NAC), 1% hydrogen peroxide, 50 mM Tris plus 3.5 mM EDTA (Tris-EDTA), and 20 mM THAM-8 mM EDTA (THAM-EDTA). Treatment was considered to be efficacious against individual isolates if a significant difference (P < 0.05) in disruption or killing of bacteria was observed.