Table 3. Comparison of VCS progressors and non-progressors.
Parameter | Progressors (n = 34) | Non-progressors (n = 115) | P |
---|---|---|---|
Age (years) | 63.15 ± 12.11 | 57.24 ± 12.9 | 0.019 |
Gender (male %) | 61.8 | 51.3 | 0.283 |
Diabetes (%) | 47.1 | 44.3 | 0.780 |
Cardiovascular | |||
BMI (kg/m2) | 22.19±2.41 | 22.85±3.64 | 0.224 |
Previous CVD (%) | 38.2 | 32.2 | 0.511 |
Smoking habit (%) | 41.2 | 40.9 | 0.974 |
Antihypertensive drugs (%) | |||
RAS blockers | 55.9 | 55.7 | 0.981 |
Beta-blockers | 44.1 | 53 | 0.360 |
CCB | 58.8 | 45.2 | 0.163 |
Anti-platelet agents (%) | |||
Statins (%) | 35.3 | 29.6 | 0.525 |
Ca-based P binder (%) | 67.6 | 84.3 | 0.031 |
Vitamin D analogue (%) | 26.5 | 27 | 0.955 |
HD | |||
Dialysis duration (months) * | 76 (64–108) | 76 (61–121) | 0.475 |
spKt/V | 1.58 ± 0.20 | 1.59 ± 0.20 | 0.670 |
RAGE | |||
Log S100A12 (ng/mL) | 6.02 ± 0.85 | 5.63 ± 0.83 | 0.016 |
Log sRAGE (pg/mL) | 7.54 ± 0.54 | 7.60 ± 0.67 | 0.612 |
Log IL-6 (pg/mL) | 0.49 ± 0.69 | 0.65 ± 0.71 | 0.238 |
Laboratory (Time-averaged) | |||
HDL-C (mg/dL) | 40.5 ± 10.92 | 41.62 ± 11.85 | 0.624 |
LDL-C (mg/dL) | 67.22 ± 16.53 | 64.36 ± 17.75 | 0.404 |
Albumin (g/L) | 3.86 ± 0.33 | 3.88 ± 0.32 | 0.849 |
Hemoglobin (g/dL) | 10.88 ± 0.73 | 10.93 ± 0.7 | 0.763 |
Ca (mg/dL) | 8.77 ± 0.46 | 8.75 ± 0.49 | 0.879 |
P (mg/dL) | 4.62 ± 0.78 | 4.57 ± 0.91 | 0.800 |
iPTH (pg/mL) | 239.95 ± 244.33 | 270.71 ± 227.59 | 0.497 |
hsCRP (mg/dL) | 1.3 ± 1.5 | 1.18 ± 1.26 | 0.643 |
25D (ng/mL) | 11.66 ± 4.67 | 10.88 ± 3.37 | 0.280 |
1,25D (pg/mL) | 18.01 ± 4.04 | 17.31 ± 3.96 | 0.369 |
Abbreviations: BMI, body mass index; CVD, cardiovascular disease; MAP, mean artery pressure; RAS, renin-angiotensin system; CCB, calcium channel blocker; Ca, calcium; spKt/V, single pool Kt/V;; sRAGE, soluble receptor for advanced glycation end product; IL-6, interleukin 6; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TG, triglyceride; Ca, calcium; P, phosphorus;; iPTH, intact parathyroid hormone; hsCRP, highly sensitive C-reactive protein; 25D, 25-hydroxyvitamin D; 1,25D, 1,25-dihydroxyvitamin D
* Median, interquartile range