Table 3.
RNA-binding proteins and mRNA metabolism-related proteins with identified posttranslational modifications in trypanosomes
| RBP | T. brucei | T. cruzi | Posttranslational modification |
| PUF domain | |||
| PUF1 | Tb927.10.4430 | TcCLB.397937.10/TcCLB.508625.160 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[71] |
| PUF2 | Tb927.10.12660 | TcCLB.507831.110 | Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69] |
| PUF3 | Tb927.10.310 | TcCLB.508787.30/TcCLB.468005.9 | Phosphorylated in T. brucei[66,68] |
| PUF4 | Tb927.6.820 | TcCLB.509399.190/TcCLB.510073.30 | Phosphorylated in T. brucei[66,68] |
| PUF6 | Tb927.10.15870 | TcCLB.510125.10 | Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[71] Sumoylated in T. cruzi[73] |
| PUF7 | Tb927.11.14960 | TcCLB.508445.99/TcCLB.511715.100 | Sumoylated in T. cruzi[73] |
| PUF9 | Tb927.1.2600 | TcCLB.506563.10/TcCLB.503869.40 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| PUF10 | Tb927.11.6740 | TcCLB.506773.130/TcCLB.508799.70 | Arginine-methylated in T. brucei[75] |
| PUF11 | Tb927.11.10810 | TcCLB.503757.30/TcCLB.503719.39 | Phosphorylated in T. brucei[68] |
| Arginine-methylated in T. brucei[75] | |||
| RRM domain | |||
| PABP1 | Tb927.9.9290 | TcCLB.506885.70 | Phosphorylated in T. brucei[68] |
| Phosphorylated in T. cruzi[70,71] Sumoylated in T. cruzi[73] | |||
| PABP2 | Tb927.9.10770 | TcCLB.508461.140 | Phosphorylated in T. brucei[68] |
| UBP1 | Tb927.11.500 | TcCLB.507093.220 | Phosphorylated in T. cruzi[84] |
| RBP3 | Tb927.11.530 | TcCLB.507093.250 | Phosphorylated in T. brucei[68] |
| RBP8 | Tb927.7.320 | TcCLB.504165.20/TcCLB.508981.20 | Phosphorylated in T. brucei[68] |
| RBP9 | Tb927.11.12120 | TcCLB.511127.10/TcCLB.511481.70 | Phosphorylated in T. brucei[68] |
| RBP10 | Tb927.8.2780 | TcCLB.508989.30/TcCLB.509569.120 | Phosphorylated in T. brucei[66,68] |
| RBP12 | Tb927.10.12740 | TcCLB.511277.200 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[71] |
| U1 snRNP (RBP24) | Tb927.8.4830 | TcCLB.508837.140/TcCLB.511383.30 | Phosphorylated in T. brucei[68] |
| RBP28 | Tb927.3.1030 | TcCLB.511871.110/TcCLB.511863.20 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| RBP29 | Tb927.10.13720 | TcCLB.511277.580 | Phosphorylated in T. cruzi[69,71] |
| RBP30 | Tb927.5.1750 | TcCLB.505229.20/TcCLB.510823.20 | Phosphorylated in T. brucei[68] |
| RBP33 | Tb927.8.990 | TcCLB.503733.50/TcCLB.508569.90 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| RBP35 | Tb927.9.12360 | TcCLB.510741.40 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70] |
| RBP38 | Tb927.11.5850 | TcCLB.508641.180/TcCLB.508515.30 | Phosphorylated in T. brucei[68] |
| RBP42 | Tb927.6.4440 | TcCLB.509167.140 | Phosphorylated in T. cruzi[71] |
| RBSR1 | Tb927.9.6870 | TcCLB.506625.70 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[69] |
| RBSR4 | Tb927.10.3500 | TcCLB.510265.40/TcCLB.510311.50 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| DRBD2 | Tb927.9.13990 | TcCLB.510755.120/TcCLB.508413.50 | Phosphorylated in T. cruzi[69] |
| DRBD5 | Tb927.6.3480 | TcCLB.469785.40/TcCLB.507025.50 | Phosphorylated in T. brucei[68] |
| DRBD7 | Tb927.4.400 | TcCLB.507873.30/TcCLB.510689.60 | Phosphorylated in T. brucei[68] |
| DRBD10 | Tb927.11.16020 | TcCLB.507037.20/TcCLB.508707.80 | Phosphorylated in T. brucei[68] |
| DRBD11 | Tb927.3.3940 | TcCLB.503683.30/TcCLB.509999.120 | Phosphorylated in T. brucei[68] |
| DRBD13 | Tb927.8.6650 | TcCLB.506399.40/TcCLB.509243.20 | Phosphorylated in T. brucei[68] |
| DRBD17 | Tb927.8.710 | TcCLB.507649.100/TcCLB.508567.100 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| DRBD18 | Tb927.11.14090 | TcCLB.511727.190 | Arginine-methylated in T. brucei[75] |
| HNRNPH | Tb927.2.3880 | TcCLB.511109.130/TcCLB.504157.10 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70,71] Sumoylated in T. cruzi[73] |
| TRRM1 | Tb927.2.4710 | TcCLB.509317.60/TcCLB.511621.50 | Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69] Sumoylated in T. cruzi[73] |
| TRRM3 | Tb927.3.3670 | TcCLB.506989.100/TcCLB.510149.140 | Arginine-methylated in T. brucei[75] |
| PPCTI | Tb927.5.3750 | TcCLB.503619.20/TcCLB.511647.40 | Phosphorylated in T. brucei[68] |
| MRD1 | Tb927.8.4170 | TcCLB.509561.110/TcCLB.503897.90 | Phosphorylated in T. brucei[68] |
| TSR1 | Tb927.8.900 | TcCLB.509607.30/TcCLB.503715.10 | Phosphorylated in T. brucei[68] |
| NRBD1/2 (P34/P37) | Tb927.11.14000/Tb927.11.14020 | TcCLB.511727.270/TcCLB.511727.290 | Arginine methylated in T. brucei[75] |
| Conserved | Tb927.10.7030 | TcCLB.506779.100/TcCLB.511153.100 | Arginine-methylated in T. brucei[75] |
| Conserved | Tb927.11.7310 | TcCLB.506779.100/TcCLB.511153.100 | Arginine-methylated in T. brucei[75] |
| Conserved | Tb927.11.14090 | TcCLB.511727.190 | Arginine-methylated in T. brucei[75] |
| Conserved | Tb927.11.6240 | TcCLB.506297.230/TcCLB.510101.80 | Arginine-methylated in T. brucei[75] |
| Zinc finger domains | |||
| ZFP1 | Tb927.6.3490 | TcCLB.511511.6 | Phosphorylated in T. brucei[66,68] |
| ZFP3 | Tb927.3.720 | TcCLB.509719.69/TcCLB.509231.39 | Phosphorylated in T. brucei[68] |
| ZC3H5 | Tb927.3.740 | TcCLB.511867.10/TcCLB.507775.10 | Phosphorylated in T. brucei[68] |
| ZC3H7 | Tb927.3.1340 | TcCLB.509233.210 | Phosphorylated in T. brucei[68] |
| ZC3H8 | Tb927.3.5250 | TcCLB.510143.120/TcCLB.508409.310 | Phosphorylated in T. brucei[68] |
| Arginine-methylated in T. brucei[75] | |||
| ZC3H11 | Tb927.5.810 | TcCLB.507305.40 | Phosphorylated in T. brucei[68,85] |
| ZC3H12 | Tb927.5.1570 | TcCLB.510819.119/TcCLB.506739.99 | Phosphorylated in T. brucei[86] |
| ZC3H13 | Tb927.5.1580 | No homologue | Phosphorylated in T. brucei[66,68] |
| ZC3H17 | Tb927.7.930 | TcCLB.508879.10/TcCLB.508215.10 | Phosphorylated in T. brucei[68] |
| ZC3H18 | Tb927.7.2140 | TcCLB.511807.160 | Phosphorylated in T. brucei[68] |
| ZC3H20 | Tb927.7.2660 | TcCLB.503567.9/TcCLB.506859.204 | Phosphorylated in T. brucei[68] |
| ZC3H21 | Tb927.7.2670 | TcCLB.506859.230/TcCLB.511817.10 | Phosphorylated in T. brucei[68] |
| ZC3H22 | Tb927.7.2680 | TcCLB.506859.240/TcCLB.511817.20 | Phosphorylated in T. brucei[68] |
| ZC3H23 | Tb927.7.4980 | TcCLB.509149.20/TcCLB.508175.350 | Phosphorylated in T. brucei[68] |
| ZC3H28 | Tb927.9.9450 | TcCLB.506885.200/TcCLB.510729.220 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70] |
| ZC3H29 | Tb927.9.9520 | TcCLB.510729.210/TcCLB.506885.204 | Phosphorylated in T. brucei[68] |
| ZC3H30 | Tb927.10.1540 | TcCLB.506977.110 | Phosphorylated in T. brucei[68] |
| ZC3H31 | Tb927.10.5150 | TcCLB.506009.10/TcCLB.510295.59 | Sumoylated in T. cruzi[73] |
| ZC3H32 | Tb927.10.5250 | TcCLB.503795.10 /TcCLB.506679.10 | Phosphorylated in T. brucei[68] |
| ZC3H34 | Tb927.10.12330 | TcCLB.507787.140/TcCLB.507625.70 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| ZC3H35 | Tb927.10.12740 | TcCLB.511263.30/TcCLB.507831.40 | Phosphorylated in T. brucei[68] |
| ZC3H37/38 | Tb927.10.12780 | TcCLB.507831.20/TcCLB.511267.20/ TcCLB.511263.50 | Phosphorylated in T. brucei[68] |
| ZC3H39 | Tb927.10.14930 | TcCLB.508895.50 | Phosphorylated in T. brucei[68] |
| ZC3H40 | Tb927.10.14950 | TcCLB.508895.60/TcCLB.506211.60 | Phosphorylated in T. brucei[66,68] Phosphorylated in T. cruzi[69,71] |
| ZC3H41 | Tb927.11.1980 | TcCLB.508355.330/TcCLB.508357.9 | Phosphorylated in T. brucei[68] |
| ZC3H43 | Tb927.11.7450 | TcCLB.511151.20/TcCLB.508241.90 | Phosphorylated in T. brucei[68] |
| ZC3H44 | Tb927.11.7890 | TcCLB.506933.50 | Phosphorylated in T. brucei[68] |
| ZC3H46 | Tb927.11.16550 | TcCLB.507089.30/TcCLB.504085.70 | Phosphorylated in T. brucei[68] |
| ZC3H47 | Tb927.6.4960 | TcCLB.506945.210 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[69] |
| Conserved | Tb927.11.3970 | TcCLB.509229.90/TcCLB.506733.140 | Phosphorylated in T. brucei[68] |
| Conserved | Tb927.9.14120 | TcCLB.510759.100/TcCLB.506999.120 | Arginine-methylated in T. brucei[75] |
| Other | |||
| NOP44/46 | Tb927.8.760 | TcCLB.510859.17/TcCLB.510859.10 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| SMD2 | Tb927.2.5850 | TcCLB.508667.49/TcCLB.511189.80 | Phosphorylated in T. brucei[68] |
| DCL2 | Tb927.3.1230 | No homologue | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| CAF1 | Tb927.6.600 | TcCLB.511827.60/TcCLB.510535.60 | Phosphorylated in T. brucei[68] |
| Not1 | Tb927.10.1510 | TcCLB.509247.30 | Phosphorylated in T. cruzi[70] |
| XRNA | Tb927.7.4900 | TcCLB.507817.80 | Phosphorylated in T. cruzi[69] |
| ALBA3 | Tb927.4.2040 | TcCLB.510877.40 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| ALBA4 | Tb927.4.2030 | TcCLB.510877.30 | Phosphorylated in T. brucei[68] Arginine-methylated in T. brucei[75] |
| eIF4E | Tb927.11.11770 | TcCLB.508827.30 | Phosphorylated in T. brucei[68] Phosphorylated in T. cruzi[70] |
| Tb927.6.1870 | TcCLB.509037.40/TcCLB.421959.10 | Phosphorylated inT. brucei[68] | |
| eIF4G2 | Tb927.9.5460 | TcCLB.508277.340/TcCLB.506445.20 | Phosphorylated in T. brucei[68] |
| Tb927.11.10560 | TcCLB.510285.100/TcCLB.504827.130 | Phosphorylated in T. brucei[68] | |
| eIF4G5 | Tb927.8.4500 | TcCLB.508989.90 | Phosphorylated in T. brucei[68] |
RBP: RNA-binding protein; RRM: RNA-recognition motif.