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. 2016 Feb 26;6:22093. doi: 10.1038/srep22093

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BV interacts with enolase decreasing its activity and glycolysis and, in turn, cell cycle progression. Moreover, BV and haem modulates phosphorylation of Eukaryotic Initiation Factor 2α (eIF2α). Phosphorylated eIF2α is a stress response factor which acts in the reduction of translation to a basal level and consequently the arrest of the cell cycle of P. falciparum. RBC: Red Blood Cell. PM: Plasmodium falciparum plasma membrane.