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. 2016 Feb 26;6:22090. doi: 10.1038/srep22090

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Copyright © 2016, Macmillan Publishers Limited

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(a) PS341 reduces migration of HCC and CRC cells in wound-healing assays. DMSO or PS341 were added into the medium of HepG2, Huh7, HT29 and LoVo cells after the artificial wound. Migration rates were calculated by healing area/wound area 24 h later. Scale bar = 50 μm. (b) PS341 negatively regulates the adhesion of HCC and CRC cells to laminin. (c) PS341 significantly suppresses the migration of cancer cell lines with transwell analysis. Scale bar = 25 μm. (d) PS341 significantly inhibits the invasion of cancer cell lines with boyden chamber analysis. Scale bar = 25 μm. (e) PS341 decreases expression of MMP2 and MMP9 in HCC and CRC cells in the PCR and RT-PCR analysis. The full-length gels are presented in Supplementary Fig. 1. The whole assay was repeated three times. Data are presented as mean ± SD. *P < 0.05, **P < 0.01.