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. 2016 Feb 26;6:21907. doi: 10.1038/srep21907

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Copyright © 2016, Macmillan Publishers Limited

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(A) The 7th TM domain of the human serotonin 5-HT7 receptor displays a CARC motif (yellow) in the exofacial leaflet and a CRAC motif (green) in the cytoplasmic leaflet. The energy of interaction between each motif and cholesterol is indicated under the amino acid sequence. (B) Distinct views of the TM domain with cholesterol in yellow bound to CARC and cholesterol in green bound to CRAC. (C) Interaction of the CARC and CRAC peptides derived from the 7th TM domain of the human serotonin 5-HT7 receptor with cholesterol monolayers. Standard colors are used for the electrostatic potential surface rendering of TM domains: positive in blue, negative in red and neutral in white.