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. 2016 Feb 26;6:22091. doi: 10.1038/srep22091

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(a) Genetic organization of the haliangicin biosynthetic gene cluster (hli). (b) A proposed biosynthetic pathway for haliangicin (1). AT₁ in module 2 is inactive, but no complementary trans-AT is found in hli. The dashed arrows indicate the unnatural pathways in the gene-disrupted strains of the heterologous host M. xanthus c10-11C/c7-6E. Abbreviations: ACAD, acyl-CoA dehydrogenase; ACP, acyl carrier protein; AT, acyl transferase; DH, dehydratase; ECH, enoyl-CoA hydratase; EPO, epoxidase; ER, enoyl reductase; FkbH, FkbH-like protein; HCS, HMG-CoA synthase; KR, ketoreductase; KS, ketosynthase; MβL-TE, metallo β-lactamase-type thioesterase; O-MT, O-methyltransferase; 3HCDH, 3-hydroxyacyl-CoA dehydrogenase.