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. 2016 Feb 26;6:22091. doi: 10.1038/srep22091

Table 1. Proposed functions of the proteins involved in haliangicin biosynthesis.

Protein Size (aa) Proposed function Top-hit homologues (Origin) Similarity/ identity (%)
HliA 608 ABC transporter ABC transporter protein (Sorangium cellulosum), CCE88383 58/34
HliB 609 ABC transporter ABC transporter protein (Sorangium cellulosum), CCE88383 44/24
HliC 259 enoyl-CoA hydratase enoyl-CoA hydratase (Nostoc punctiforme PCC 73102), YP_001866568 74/53
HliD 217 O-methyltransferase JerF (Sorangium cellulosum), ABK32292 62/45
HliE 303 metallo-β-lactamase type TE β-lactamase (Rhodothermus marinus SG0.5JP17-172), YP_004824011 67/49
HliF 1372 PKS (KS-AT-O-MT-ACP) MtaF (Stigmatella aurantiaca DW4/3-1), YP_003953631 62/45
HliG 1966 PKS (KS-AT-DH-KR-ACP) MxaD (Stigmatella aurantiaca), AAK57188 57/42
HliH 367 FkbH-like protein HAD superfamily phosphatase (Sorangium cellulosum), CCE88385 78/62
HliI 387 acyl-CoA dehydrogenase acyl-CoA dehydrogenase (Sorangium cellulosum), CCE88384 73/57
HliJ 83 ACP hypothetical protein (Paenibacillus dendritiformis), WP_006675272 76/57
HliK 287 3-hydroxyacyl-CoA dehydrogenase hydroxyacyl-CoA dehydrogenase (Sorangium cellulosum), CCE88386 79/66
HliL 950 PKS (KS-AT) polyketide synthase (Chondromyces crocatus), CBD77738 61/48
HliM 407 HMG-CoA synthase HMG-CoA synthase (Nostoc punctiforme PCC 73102), YP_001866566 65/48
HliN 83 ACP acyl carrier protein (Nostoc sp. 'Peltigera membranacea cyanobiont'), AGH69805 81/56
HliO 277 enoyl-CoA hydratase enoyl-CoA hydratase/isomerase (Nostoc punctiforme PCC 73102), YP_001866567 58/42
HliP 2890 PKS (KS-ACP-KS-AT- DH-KR-ACP) polyketide synthase (Myxococcus xanthus DK 1622), YP_632696 55/42
HliQ 861 AT-ACP-O-MT putative methoxymalonyl-CoA synthase (Sorangium cellulosum), AAK19884 59/44
HliR 392 acyl-CoA dehydrogenase acyl-CoA dehydrogenase (Herbidospora cretacea), WP_030450088 69/55
HliS 626 AT-ACP MxaF (Stigmatella aurantiaca), AAK57190 57/43
HliT 2225 PKS (KS-AT-DH-ER- KR-ACP) polyketide synthase (Sorangium cellulosum), CCE88378 61/44
HliU 463 epoxidase FAD-binding monooxygenase (Geodermatophilus obscurus DSM 43160), YP_003408356 56/42