Table 1.
Summary of the association between estrogen receptor isoforms and gastric cancer
| Estrogen receptors | Isoform | Association with gastric cancer |
| ERα | ERα66 | No significant correlation between ERα66 and gastric cancer is found[27] |
| No positive significant difference in both male and female[27,28] | ||
| Incidence higher in poorly differentiated adenocarcinoma[28] | ||
| Association with diffused type gastric cancer is found[31] | ||
| Associated with poor overall survival[31] | ||
| ERα46 | No reported result has been up to date | |
| ERα36 | Expressed highly in gastric cancer[34] | |
| Expression correlated with lymph node metastasis[34] | ||
| Expressed in plasma membrane and cytoplasm of gastric cancer[34] | ||
| ERβ | ERβ1 | Associated with low tumor grades[32] |
| ERβ2 | Presence could have protective effect against invasion[32] | |
| ERβ3 | Absence of ERβ a significant independent prognostic factor for poor OS[15] | |
| ERβ4 | ERβ5 is associated with PTNM stage[39] | |
| ERβ5 |
ER: Estrogen receptor; OS: Overall survival.