Table 1.
Clinical characteristics of mice fed experimental diets for 4 or 8 wk
| Group | n | Daily food consumption (g) | Liver weight (g) | Hepatic TG (mg/g liver) | Hepatic FFA (mg/g liver) | Serum ALT (IU/L) |
| MCS 4 wk | 6 | 6.4 ± 0.5 | 2.3 ± 0.03 | 102 ± 30 | 0.82 ± 0.06 | 30 ± 5.4 |
| MCD + saline 4 wk | 8 | 3.4 ± 0.5b | 1.6 ± 0.02b | 314 ± 17b | 1.24 ± 0.18b | 209 ± 30b |
| MCD + exendin-4 4 wk | 8 | 3.2 ± 0.6 | 1.3 ± 0.04d | 200 ± 40d | 1.05 ± 0.11 | 190 ± 29 |
| MCS 8 wk | 6 | 6.2 ± 0.5 | 2.2 ± 0.03 | 43 ± 9 | 0.64 ± 0.01 | 32 ± 16 |
| MCD + saline 8 wk | 8 | 3.4 ± 0.4a | 1.4 ± 0.04a | 137 ± 31a | 0.87 ± 0.06a | 103 ± 41a |
| MCD + exendin-4 8 wk | 8 | 3.0 ± 0.6 | 1.1 ± 0.03c | 96 ± 19 | 0.69 ± 0.06 | 81 ± 24 |
a
P < 0.05, vs MCS 8 wk;
b
P < 0.01, vs MCS 4 wk;
c
P < 0.05, MCD + saline 8 wk;
d
P < 0.01, vs MCD + saline 4 wk. TG: Triglyceride; FFA: Free fatty acid; ALT: Alanine aminotransferase; MCS: Methionine-choline-sufficient diet; MCD: Methionine-choline-deficient diet.