Figure 1. Overview of quantitative chemical proteomics approach for identifying the targets of curcumin.

(a) Overall workflow for in situ profiling of potential curcumin targets in live cells. (b) The structure of curcumin and curcumin-based probe (Cur-P). (c) Dose-dependent inhibition of HCT116 cell proliferation by curcumin and Cur-P. (d) Synthetic scheme of Cur-P. Error bars represent s.d. in three independent replicates in (c).