| CCDC88A |
Gα-interacting vesicle-associated (GIV) protein (a.k.a. Girdin/HkRP1, APE). |
Cytoskeleton associated guanine nucleotide exchange factor for trimeric G protein, Giα that modulates growth factor signaling. |
Prometastatic (increases invasion, imparts chemoresistance, stem-ness, angiogenesis, survival). See Table S1. |
Glioma, Esophagus, Gastric, Lung, Liver, Breast, Colon and Prostate. |
| CCDC88C |
Dvl-associating protein with a high frequency of leucine residues (Daple) |
Guanine nucleotide exchange factor for trimeric G protein, Giα that enhances non-canonical Wnt signaling. |
Tumor suppressor in the normal epithelium; Proinvasive role in cancer cells. See Table S1. |
Colon, Gastric |
| NUCB1 |
Nucleobindin1/Calnuc |
EF-hand containing calcium binding protein and a guanine nucleotide exchange factor for trimeric G protein, Giα that is required for unfolded protein response. The role of its GEF function remains unknown. |
Possible role in survival via regulation of UPR. See Table S1 |
Colon, Gastric |
| NUCB2 |
Nucleobindin2/Nesfatin-1/NEFA |
|
Increases migration, proliferation and invasion. See Table S1. |
Gastric, Prostate, Breast |
| MACC1 |
Metastasis Associated In Colon Cancer 117
|
SH3 domain-containing protein that regulates HGF/c-Met pathway17
|
Increases migration, invasion, proliferation, survival and angiogenesis 53,54,55,56,57,58,59,60,61,62,63,64
|
Glioma, Esophagus, Lung Gastric, Liver, Breast, Colon Prostate, Klatskin, Salivary gland, Nasopharygeal and oral (tongue), Ovary, Cervix |
| S100A4 |
S100 Calcium Binding Protein A4 (a.k.a Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog) |
EF-hand containing calcium binding protein that is member of the S100 calcium-binding protein family secreted by tumor and stromal cells |
Supports tumorigenesis by stimulating angiogenesis. |
Colon, Bladder, Lung, Breast, Prostate, Thyroid, Esophageal, Gallbladder, Gastric. |
