Table 3. Kaplan-Meier survival analysis for individual CTC markers.

		PFS (months)			OS (months)
		Marker levels*		Median	95% CI	P value	Median	95% CI	P value
CCDC88A	Low			10,3	8,9–11,8	0,007	23,3	16,8–29,9	0,359
	High	7,0	2,0–11,0	9,3	7,5–11,1
CCDC88C	Low	10,0	8,8–11,2	0,003	24,2	20,5–27,8	0,003
	High	5,6	3,2–8,0		7,1	4,2–10,0
CCDC88Cfl	Low	10,0	8,8–11,2	0,003	23,3	19,9–26,8	0,047
	High	5,6	2,3–8,9		8,9	5,1–12,7
NUCB1	Low	10,6	9,5–11,6	<0,001	24,1	20,5–27,8	0,001
	High	5,2	3,6–6,8		8,7	5,7–11,7
NUCB2	Low	10,3	9,1–11,6	0,005	23,3	19,8–26,8	0,091
	High	6,6	0,9–12,3		9,3	6,8–11,9
MACC1	Low	10,0	8,9–11,0	0,094	23,2	17,1–29,3	0,101
	High	6,6	3,8–9,4		7,0	2,3–11,6
S100A4	Low	10,0	8,6–11,4	0,033	23,2	17,9–28,5	0,300
	High	8,5	2,6–14,4		10,4	5,4–15,3

Abbreviations: CTC, Circulating Tumor Cells; PFS, Progression Free Survival; OS, Overall Survival;

CI, Confidence Interval. Times in months.

*Marker high and low levels were calculated based on 75% percentile for each marker.