Table 5. Multivariate Cox proportional hazard regression analysis.
| Covariates | N | PFS |
χ2(**) | OS |
χ2(**) | ||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Number of metastatic locations (1,2 vs other) | 51 | 0,72 (0,26–1,99) | 0,524 | <0,001 | 4,38 (1,35–14,20) | 0,014 | <0,001 |
| Lung mets. (yes vs no) | 3,75 (1,73–8,15) | 0,001 | 1,85 (0,84–4,01) | 0,125 | |||
| ECOG PS (2 vs ≤1) | 1,790,75–4,29) | 0,191 | 2,88 (1,22–6,78) | 0,016 | |||
| GEF marker cluster | 5,20 (2,15–12,57) | <0,001 | 2,69 (1,09–6,63) | 0,031 | |||
| S100A4/MACC1 cluster | 0,93 (0,43–2,00) | 0,857 | 0,91 (0,40–2,07) | 0,822 | |||
Abbreviations: PFS, Progression Free Survival; OS, Overall Survival; HR, Hazard Ratio; CI, Confidence Interval; ECOG PS, Eastern Cooperative Oncology Group performance score.
(**) Significance of a Chi-square test for multivariate models.