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. 2016 Feb 26;6:21582. doi: 10.1038/srep21582

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Effects of E139 (A), E121 (B), E138 (C), E122 (D) and BRG 19 (E) on reaction latency of mice to the hot plate (55 ± 1 °C) at different times after administration (n = 8–12 per group). *P < 0.05 and **P < 0.01 compared to vehicle-treated mice.