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. 2016 Feb 26;6:21582. doi: 10.1038/srep21582

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Effects of (A) a GABA_A receptor antagonist bicuculline and (B) a GABA_B receptor antagonist CGP 35348 hydrate on the antinociceptive effects of E139 in BALB/c mice (n = 8) at 1.5 h after administration in the hot plate test. **p < 0.01 compared to mice treated with vehicle and ^#p < 0.05 and ^##p < 0.01 to mice treated with E139 at the same time point after treatment.