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. 2016 Feb;13(2):555–564. doi: 10.1016/j.hrthm.2015.10.003

Figure 1.

Figure 1

Schematic of the experimental procedure for action potential measurements in human atrial trabeculae. A: Time-matched control experiments: after an equilibration period of ≥60 minutes at a stimulation rate of 1 Hz, the effective refractory period was measured (b). Stimulation rate was then increased successively, with 2 minutes for stabilization (a) and 2 minutes for the measurement of effective refractory period (b). B: After returning to 1 Hz, preparations were exposed to XEN-D0103 for 60 minutes before going through another set of rate increases.