Table 2.

Possible outcome measures for use in tracking episodes of AKI

	Entity resolution	Initial encounter		Subsequent encounters
		Kidney Health	Overall health	Kidney Health	Overall health
Population	Name Unique identifier Gender Date of birth	AKI detection results/tag. Serum creatinine measurements (baseline, during AKI and recovery).	ICD codes Comorbidities Complications Resource utilization e.g. length of stay, critical care admission.	All subsequent AKI episodes, stages and timing. eGFR. Albuminuria. CKD stage. Need for RRT.	Re-hospitalization. New diagnoses, ICD codes: CV events, cancer, infection, fracture, MAKE, MARCE. Time and cause of death.
Patient	Name Unique identifier Sex Date of birth	AKI detection results/tag AKI stage, duration and setting AKI etiology Need for acute RRT Nephrology consult	Setting of AKI, exposures and co-existing illness. Blood pressure. Procedures.	eGFR. Albuminuria. CKD stage. Need for RRT. Blood pressure.	Comorbidities. Complications. Quality of life/dependency.
Management	Name Unique identifier Gender Date of birth	Treatment given for AKI. AKI follow up plans. Medications. Discharge quality indicators. Education (including patient).	Medications (including those stopped/temporarily suspended). Frailty measures. Patient reported outcomes and symptoms.	CKD care. Secondary prevention of AKI episodes. Medications.	Functional recovery. Cardiovascular risk. Frailty measures. Patient reported outcomes and symptoms.
Research		Biomarkers.	Specific therapies. Improved methods of capturing patient reported data.	Therapies to facilitate recovery. Use of biomarkers to predict risk/recovery.	Therapies to improve systemic outcomes.

AKI acute kidney injury, ICD International Classification of Diseases, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, RRT renal replacement therapy, MAKE major adverse kidney events, MARCE major adverse renal and cardiovascular events