Table 4. Joint effect of rs3783553 polymorphism and HPV16 serology on risk of OSCC, stratified by drinking status.

Risk groups	HPV16 status	Patients (n=325)		Controls (n=335)		Adjusted OR (95% CI)*
		No.	%	No.	%	OSCC	SCCOP	OC
Never-drinkers
Ins/Del + Ins/Ins	-	28	37.3	53	55.8	1.0	1.0	1.0
Del/Del	-	22	29.3	33	34.7	1.4(0.6-2.9)	1.7(0.6-4.8)	1.3(0.5-3.2)
Ins/Del + Ins/Ins	+	11	14.7	6	6.3	4.0(1.3-12.8)	8.9(2.4-33.1)	1.5(0.3-8.8)
Del/Del	+	14	18.7	3	3.2	13.0(3.2-52.9)	29.1(6.5-131.1)	2.3(0.3-19.3)
Ever-drinkers
Ins/Del + Ins/Ins	-	100	40.0	142	59.2	1.0	1.0	1.0
Del/Del	-	75	30.0	65	27.1	1.7(1.1-2.5)	2.3(1.3-4.0)	1.3(0.7-2.2)
Ins/Del + Ins/Ins	+	40	16.0	22	9.1	2.6(1.4-4.7)	4.9(2.5-9.4)	0.7(0.3-1.8)
Del/Del	+	35	14.0	11	4.6	4.5(2.2-9.4)	10.4(4.8-22.6)	0.4(0.1-2.0)

^*Adjusted for age, sex, and tobacco smoking status