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Effect of GLS inhibition by BPTES on cell (a) clonogenic viability (b) cell toxicity and (c) glutathione excretion in H460 and A549 cells. Shown are mean ± SD of three independent experiments. (d) Representative bright field images (40x magnification) of H460 and A549 cells after 48 hrs treatment with various concentrations of BPTES or culturing in glutamine-free (Gln−) media.
