. Author manuscript; available in PMC: 2016 Feb 26.

Published in final edited form as: Am J Med Genet A. 2015 Feb 5;0(4):701–707. doi: 10.1002/ajmg.a.36953

TABLE I.

Association of Maternal Thyroid Disease With Craniosynostosis, National Birth Defects Prevention Study, 1997–2007

Affected suture(s)	No. cases with and without thyroid disease^*	AOR (95% CI), adjusted for maternal age^**
Any	37/1030	1.4 (0.9, 1.9)
Sagittal	19/547	1.3 (0.8, 2.1)
Metopic	6/188	1.3 (0.6, 3.0)
Coronal	6/181	1.2 (0.5, 2.9)
Lambdoidal	0/32	—
Multiple	6/79	3.0 (1.3, 6.9)

The sum of the two numbers in the column equals the total number of cases; eg, 37 + 1030 = 1067 cases with any affected suture. Number of controls with and without thyroid disease was 191 and 8303, respectively.

^**

Adjusted for maternal age as <25, 25–29, 30–34, 35+ years.