Table 1. PBM sample delivery protocols from animal model studies.
| Retinal disease | Species | PBM delivery device | Mode of PBM application | Mode of disease induction | Pre-treatment | Concurrent treatment | Post-treatment |
| Model of AMD[44] | SD rats | LED array (λ=670nm) | At 2.5 cm distance from the eye | Light damage with 1000 lx for 24h | Once daily for 5d prior to light damage, 3min each, energy fluence of 9 J/cm2 | None | None |
| Once on the day prior to light damage | Twice during the light-damage period | Once after the light-damage period | |||||
| None | None | Once daily for 5d, 3min each, at energy fluence of 9 J/cm2 | |||||
| Model of diabetic retinopathy[35] | Lewis rats | LED array (λ=670nm) | Whole-body irradiation | Streptozoto-cin-induced diabetes | None | None | Once daily for 9wk, 240s each, at 6.0 J/cm2 total energy density |
| Model of ROP[53] | New-born C57BL/6J mice or SD rats | LED array (λ=670nm) | At 2.5 cm distance from the eye | Oxygen-induced retinal damage over 5d (mice), 18d (rats) | None | Daily, 3min each, at 9 J/cm2 | None |
| Model of methanol toxicity[33] | SD rats | LED array (λ=670nm) | Whole-body irradiation | Methanol intoxication | None | None | 2.5min sessions at 5, 25, and 50h after methanol poisoning, at 4 J/cm2 |
λ: Wavelength; AMD: Age-related macular degeneration; SD: Sprague-Dawley; LED: Light-emitting diode; ROP: Retinopathy of prematurity.