Table 3.
Combinatorial antibacterial activity of the best ABgp46/outer membrane permeabilizers (EDTA, citric, and malic acid) formula against broad range of planktonic Gram-negative pathogens.
| Bacterial species | ABgp46/EDTA | ABgp46/citric | ABgp46/malic |
|---|---|---|---|
| E coli O157:H7 | 0.32 ± 0.15 | 2.78 ± 0.37∗ | 2.08 ± 0.32∗ |
| A. baumannii #2 | >5.00† | >5.00† | >5.00† |
| P. aeruginosa PAOI | 4.35 ± 0.20 | 4.25 ± 0.31 | 4.51 ± 0.22 |
| S. typhimurium LT2 | 0.57 ± 0.20 | 4.24 ± 0.39∗ | 4.07 ± 0.37∗ |
| C. sakazakii CECT 858 | 1.21 ± 0.38 | 2.05 ± 0.27 | 0.94 ± 0.23 |
| K. oxytoca A1CC 13182 | 0.26 ± 0.08 | 0.96 ± 0.35∗ | 0.81 ± 0.12∗ |
Averages ± standard deviations for all experiments are given for n = 4 repeats. Marked in bold are ≥1 log reduction units observed. Statistically significantly (Student’s t-test and P < 0.05) conditions between ABgp46/EDTA and ABgp46/organic acids are indicated with asteristic. †The detection level of 10 CFU/mL has been reached.