Table 2.
Meta-analyses on microvolt T-wave alternans testing for arrhythmic risk stratification in patients with with low left ventricular ejection fraction of ischemic and nonischemic etiology
| Meta-analysis | Studies, n | Patients, n | Relative risk (95% CI) | P | NPV (%) |
| Studies with only ischemic cardiomyopathy patients | |||||
| Chen et al. (2013)70 | 7 | 3385 | 1.65 (1.32–2.07) | <0.001 | NR |
| Studies with only nonischemic cardiomyopathy patients | |||||
| Golberger et al. (2014)71 | 12 | 1631 | 3.25 (2.04–5.16) | <0.001 | 97 |
| Studies with mixed ischemic and nonischemic cardiomyopathy patients | |||||
| Gehi et al. (2005)67 | 19 | 2608 | 3.77 (2.39–5.55) | NR | 97 |
| Chan et al. (2010)66 | 9 | 3939 | 1.95 (1.29–2.96) | 0.002 | NR |
| Calò et al. (2011)68 | 15 | 5681 | 2.40 (1.54–3.74) | NR | 95 |
| Gupta et al. (2012)69 | 20 | 5945 | 3.68 (2.23–6.07) | NR | 96 |
| Studies in which β-blockers were administered | |||||
| Chan et al. (2010)66 | 4 | 1277 | 5.39 (2.68–10.84) | <0.001 | 98 |
| Studies in which β-blockers were withheld | |||||
| Chan et al. (2010)66 | 5 | 2662 | 1.40 (1.06–1.84) | 0.02 | 91 |
CI, confidence interval; NPV, negative predictive value; NR, not reported.