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Design and synthesis of multiple‐component RNAi microsponges (Multi‐RNAi‐MSs). A, B) Synthesis of Multi‐RNAi‐MSs with different types of circular DNA. A circular DNA library was constructed using individual circular DNA templates that encode each siRNA sequence. Numerous combinations of circular DNAs can be used to generate Multi‐RNAi‐MSs, depending on the application intended.
