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. 2016 Feb 12;220(3):121–127. doi: 10.1038/sj.bdj.2016.94

Table 3. Clinical studies on SFG.

Study Country of study N Population Intervention Follow-up period Baseline caries Control Reduction in caries (%)
Möller 1973 Denmark 340 School children Sorbitol gum 2 years NR No gum 10%
Scheinin 1975 Finland 100 Young adults Xylitol gum 1 year NR Sucrose gum 91%
Glass 1983 USA 540 Children aged 7–11 Sorbitol gum twice a day 2 years NR No gum 2%
Isokangas 1989 Finland 324 Children aged 11–12 Xylitol gum 5 years NR No gum 45%
Kandelman 1990 Canada 274 Children aged 8–9 15% and 65% Xylitol gum 2 years NR No gum 61 – 66%
Mäkinen 1995 Belize 1,277 Children aged 10 Sorbitol, xylitol or combinations 40 months NR No gum 17 – 71%
Mäkinen 1996 Belize 510 Children aged 6 Sorbitol, xylitol or combinations 24 months NR No gum 28 – 69%
Beiswanger 1998 Puerto Rico 1,402 Children in grades 5–7 Sorbitol gum, daily after meals. 2 years NR No gum 12%
Alanen 2000 Estonia 740 Children aged 10 Xylitol gum 3 years Control group DMFS: 2.18 (SD 3.30) No gum 54%
            Xylitol group DMFS: 2.10 (SD 2.55)    
            Measurement excludes surfaces with incipient caries    
Szöke 2001 Hungary 547 School children aged 8–13 Sorbitol stick, daily after meals 2 years Control group DMFS: 1.94 (2.85) No gum 33%
            Gum group DMFS: 1.69 (SD 2.64)    
            Measurement excludes surfaces with incipient caries    
Machiulskiene 2001 Lithuania 432 Children aged 9–14 Sorbitol, xylitol, HIS gum 3 years Control group DMFS: 6.4 (SD 4.3) No gum 25 – 33%
            Xylitol gum group DMFS: 5.0 (SD 3.9)    
            Measurement includes all stages of caries formation    
Kovari 2003 Finland 921 Children in day care centres Xylitol gum 6 years NR No gum Paper could not be retrieved
Peng 2004 China 1,143 Children aged 6–7 Sorbitol, xylitol, carbamide gum 2 years Control group DMFS: 0.05 (SD 0.30) No gum 42%
            Gum group DMFS: 0.07 (SD 0.32)    
            Measurement includes all stages of caries formation    
Morgan 2008 Australia 2,720 Children aged 11–13 CPP-ACP gum 2 years Control group D1MFS: 2.80 (SD 3.85) SFG 17%
            Gum group D1MFS: 2.76 (SD 3.79)    
            Measurement includes all stages of caries formation    
Tao 2013 China 157 Children aged 8–9 Tea polyphenol gum 2 years Control group DMFS: 0.36 (SD 0.79) No gum 58%
            Gum group DMFS: 0.56 (SD 1.13)    
            Measurement includes all stages of caries formation