Table 1. Mean ± SEM body weight, heart weight and the heart-to-body weight ratio of WT and db/db mice groups.

Mice group	Early time point			Late time point
	Body weight (g)	Heart weight (mg)	Heart/body weight ratio	Body weight (g)	Heart weight (mg)	Heart/body weight ratio
WT RAS	18.9 ± 0.5a	134.4 ± 4.5	7.1 ± 0.2d,e	23.7 ± 0.5a	146.8 ± 3.5c	6.2 ± 0.2d
db/db RAS	32.5 ± 0.8a	140.0 ± 3.1	4.4 ± 0.1d	38.6 ± 1.4a,b	183.1 ± 9.1c	4.9 ± 0.3d
WT Sham	21.1 ± 0.2a	125.0 ± 3.7	5.9 ± 0.2e,d	25.8 ± 0.4b	143.3 ± 5.0	5.6 ± 0.1e
db/db Sham	33.3 ± 1.2a	131.4 ± 6.3	4.0 ± 0.1e	32.7 ± 1.6b	131.4 ± 5.8c	4.2 ± 0.3e

Notes.

^ap < 0.001 = Body weight comparison between db/db RAS vs WT RAS at both early and late time points, WT sham vs db/db sham early time point.

^bp < 0.05 = Body weight comparison between WT sham vs db/db sham late time point, db/db RAS vs db/db sham at late time point.

^cp < 0.001 = Heart weight comparison between db/db RAS vs WT RAS at late time point, db/db RAS vs db/db sham at late time point.

^dp < 0.001 = Heart-to-body weight ratio comparison between db/db RAS vs WT RAS at both early and late time points, WT sham vs db/db sham early time point.

^ep < 0.05 = Heart-to-body weight ratio comparison between WT sham vs db/db sham late time point, WT RAS vs WT sham early time point.