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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2016 Mar;19(2):103–110. doi: 10.1097/MCO.0000000000000254

Figure 2.

Figure 2

Biosynthesis of monounsaturated fatty acids (MUFA) in mouse and human skin. Human skin expresses only FADS2 while mice and all other animals’ skin expresses only Scd1. Both SCD1 and FADS2 are expressed and their resulting enzymes are active in liver and other organs of both humans and mice. Mouse: Scd1 mediates 18:0 conversion to 18:1n-9 and 16:0 conversion to 16:1n-7; Human: FADS2 mediates conversion of 16:0 to 16:1n-10 but has no effect on any other saturated fatty acid (e.g. 18:0 no enzymatic activity).