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Disease Activity Scores in 28 joints using the erythrocyte sedimentation rate (DAS28-ESR) throughout the study period, by treatment group. Patients received immediate (IM) combination therapy (broken line), methotrexate (MTX) monotherapy (solid black line), or initial MTX therapy with step-up (SU) to combination therapy (solid gray line) (see Patients and Methods for details). Values are the mean ± 95% confidence interval.
