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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Biochemistry. 2012 Sep 28;51(40):7813–7815. doi: 10.1021/bi301010z

Figure 3.

Figure 3

(A) DEER percentage closed (% closed) for MDR769 protease. (B) DEER % difference between MDR769 and subtype B (17). (C) Logarithmic plot of half maximal inhibitory concentration (IC50) (12) against DEER % closed for MDR769. Inhibitors clustered into two distinct groups but ATV and APV appear to be outliers. (D) Plot of the log IC50 fold-change (12) versus the magnitude of % difference in DEER closed population (|ΔC|) between MDR769 and subtype B reveals a linear correlation. Inhibitors that exhibited low % closed population in both MDR769 and subtype B PR (IDV and NFV) are excluded from analysis.