Table 2.

Association Between Sex and Time to First Outcomes

Outcome	No. of Events			Event Rate Per 100 Patient-Years		Univariable Analysis		Multivariable Analysis*
	All Patients	Women	Men	Women	Men	HR (95% CI), Women vs Men	P Value	HR (95% CI), Women vs Men	P Value
All-cause death	881	447	434	4.32	6.72	0.64 (0.56–0.73)	<0.001	0.70 (0.59–0.83)	<0.001
All-cause hospitalization or death	2430	1382	1049	19.42	25.05	0.79 (0.73–0.86)	<0.001	0.80 (0.72–0.89)	<0.001
Cardiovascular hospitalization or death	1754	970	784	11.76	15.97	0.75 (0.68–0.83)	<0.001	0.81 (0.72–0.92)	0.001
Noncardiovascular hospitalization or death	1483	846	638	9.89	12.40	0.81 (0.72–0.89)	<0.001	0.78 (0.69–0.90)	<0.001
Heart failure hospitalization or death	716	420	296	4.43	5.02	0.89 (0.77–1.04)	0.140	0.94 (0.77–1.14)	0.51
First all-cause hospitalization	2278	1314	964	18.43	23.14	0.82 (0.75–0.88)	<0.001	0.77 (0.66–0.89)	<0.001

HR indicates hazards ratio; HF, heart failure; PCI/CABG, percutaneous coronary intervention/coronary artery bypass surgery; TIA, transient ischemic attack; COPD, chronic obstructive pulmonary disease; NT-pro-BNP, N-terminal pro-B-type natriuretic peptide.

^*Adjusted for age, obesity, New York Heart Association status, HF cause, HF hospitalization within 6 mo, comorbidities/risk factors (history of hypertension, stable angina, myocardial infarction, PCI/CABG, atrial fibrillation, diabetes, stroke/TIA, COPD/asthma, valve disease, smoking), ejection fraction capped at 60%, heart rate, systolic blood pressure, hemoglobin, ln-NT-pro-BNP, natural log-neutrophil count, glomerular filtration rate capped at 90 mL/min per 1.73 m², and all medications.

^†Death from any cause or hospitalization for protocol-specified cardiovascular cause (HF, myocardial infarction, arrhythmia, or stroke).