Table 2. The phenotypes associated with the genes uniquely expressed in each tissue*.

Tissue	Phenotype**	P-value***	Associated phenotype****
Adrenal gland	abnormal aldosterone level	2.31E-05	○
	abnormal adrenal cortex morphology	2.95E-05	○
	abnormal thoracic cage morphology	3.94E-05	×
Colon	abnormal intestinal epithelium morphology	9.57E-07	○
	abnormal exocrine gland morphology	1.19E-06	○
	abnormal crypts of Lieberkuhn morphology	3.86E-06	○
Cortex	abnormal synaptic transmission	3.29E-35	○
	abnormal CNS synaptic transmission	4.44E-34	○
	abnormal nervous system physiology	2.85E-30	○
Heart	abnormal muscle fiber morphology	3.99E-18	○
	abnormal muscle physiology	1.01E-13	○
	abnormal cardiac muscle contractility	4.13E-12	○
Kidney	abnormal urine homeostasis	7.97E-22	○
	abnormal renal/urinary system physiology	3.42E-21	○
	renal/urinary system phenotype	4.39E-18	○
Lung	abnormal blood vessel morphology	1.03E-08	×
	abnormal developmental vascular remodeling	6.16E-08	○
	abnormal lung morphology	1.01E-07	○
Placenta	prenatal lethality	2.98E-08	○
	embryonic lethality	7.27E-08	○
	abnormal embryogenesis/ development	1.43E-06	○
Spleen	abnormal blood cell physiology	1.39E-46	○
	abnormal hematopoietic system physiology	7.19E-46	○
	abnormal immune cell physiology	2.10E-43	○

* The genes that are actively expressed only in a certain tissue were selected as described in the legend for Fig. 2A. ** The phenotype which is observed when a gene is disrupted. Listed are the most frequently observed phenotypes (ranked in top 3) with the disruption of the genes uniquely expressed in each tissue. *** The probability that the number of the genes associated with the phenotype are not different between the corresponding and all genes. **** The phenotype that is associated with the corresponding tissue is marked as ○, but not associated is ×.