. Author manuscript; available in PMC: 2016 Feb 26.

Published in final edited form as: Biol Blood Marrow Transplant. 2015 Feb 3;21(5):926–933. doi: 10.1016/j.bbmt.2015.01.023

Table 3.

Clinical Outcomes by MMF Dose

Variable			Univariable			Multivariable
		N	Estimate (%)	95% CI	P-value	RR	95% CI	P-value
Neutrophil Engraftment
MMF					0.96
	2g	93	94	91–97		1.0
	3g	175	93	88–98		0.96	0.71–1.28	0.76
HLA disparity					0.20
	4/6	155	93	89–97		1.0
	5/6	97	95	91–99		1.18	0.89–1.57	0.25
	6/6	16	100			1.64	0.91–2.97	0.10
Age					0.02
	<34	26	100			1.0
	35–59	176	95	92–98		1.07	0.80–1.43	0.25
	60+	66	89	81–97		0.69	0.49–0.96	0.03
CD34 dose					0.02
	<3.5×10⁷	64	89	81–97		1.0
	≥3.5×10⁷	204	95	92–98		1.40	1.03–1.90	0.03

Platelet Engraftment (20K)
MMF					0.16
	2g	93	68	56–80		1.0
	3g	175	75	66–84		1.26	0.93–1.70	0.14
HLA disparity					0.03	--	--	--
	4/6	155	71	62–80
	5/6	97	75	63–87
	6/6	16	75	46–100
HCT-CI					0.04
	None	67	82	64–87		1.0
	1–2	66	76	62–80		0.82	0.55–1.22	0.33
	3+	129	67	57–78		0.67	0.47–0.94	0.02
CD34 dose					<0.01
	<3.5–10⁷	64	58	44–72		1.0
	≥3.5×10⁷	204	77	69–86		1.81	1.29–2.55	<0.01

Chronic GVHD
MMF					0.17
	2g	93	27	17–36		1.0
	3g	175	20	14–26		0.69	0.41–1.15	0.15
Gender					0.14
	Male	163	26	19–33		1.0
	Female	105	17	10–25		0.41	0.28–0.84	0.01
Female donor to male recipient					0.93
	No	141	22	15–29		1.0
	Yes	127	23	15–31		0.54	0.28–1.04	0.07

NRM
MMF					0.74
	2g	93	15	8–22		1.0
	3g	175	14	9–19		0.93	0.48–1.81	0.83
Disease risk					0.02
	Standard	126	9	4–14		1.0
	High	142	19	13–26		2.28	1.13–4.61	0.02
ATG					0.07	--	--	--
	No	182	12	7–16
	Yes	86	20	11–28

Relapse
MMF					0.78
	2g	93	40	29–51		1.0
	3g	175	43	35–51		1.14	0.77–1.69	0.52
Female donor to male recipient					0.16
	No	141	38	29–46		1.0
	Yes	127	46	36–55		1.33	0.92–1.92	0.13
ATG					0.05
	No	182	47	39–55		1.0
	Yes	86	31	20–41		0.56	0.36–0.87	0.01

DFS
MMF					0.88
	2g	93	40	30–50		1.0^*
	3g	175	37	30–44		1.05^*	0.77–1.43	0.74
CD34 dose					0.02
	<3.5×10⁷	64	29	19–41		1.0^*
	≥3.5×10⁷	204	41	34–48		0.69^*	0.49–0.96	0.03

OS
MMF					0.85
	2g	93	62	52–71		1.0^$
	3g	175	61	53–67		1.03^$	0.72–1.47	0.87
CD34 dose					0.03
	<3.5×10⁷	64	50	37–61		1.0^$
	≥3.5×10⁷	204	65	58–71		0.70^$	0.48–1.02	0.07

Denotes relative risk of death/relapse

Denotes relative risk of death