Figure 6.

Functional characterization of NBCs expressed in Xenopus oocytes demonstrating Na⁺-dependent pH_i recovery from a CO₂/HCO3⁻-induced acidification. The electrogenic transporters NBCe1 (A) [adapted, with permission, from 70] and NBCe2 (B) [adapted, with permission, from 326] produce a large hyperpolarization due to net negative charge movement into oocytes. Activation of the electroneutral transporters NBCn1 (C) [adapted, with permission, from 75], NBCn2/NCBE (D) [adapted, with permission, from 236], and NDCBE (E) [adapted, with permission, from 117] is not associated with hyperpolarization.