. Author manuscript; available in PMC: 2016 Feb 26.

Published in final edited form as: Compr Physiol. 2014 Oct;4(4):1605–1637. doi: 10.1002/cphy.c130005

Table 4.

SLC4 Genetic Polymorphisms Associated with Diseases

Gene	Chrom	Total SNPs	Syn	Nonsyn	Disease-associated SNP	Disease	Reference
SLC4A4	4q21	7163	56	57	Rs72650362 A/G (exon)	reduced activity^*	(346)
SLC4A5	2p13	9750	68	93	rs10177833 A/C (intron)	hypertension	(136)
SLC4A7	3p22	2357	51	73	rs7571842 A/G (intron)	hypertension	(54)
SLC4A8	12q13	2312	46	47	rs4973768 C/T (3′ UTR)	breast cancer	(7, 65, 127, 195, 201, 306)
SLC4A10	2q24	6234	46	43	rs3278 A/G (intron)	drug addiction	(142, 188, 321)
					rs13082711 C/T (5′ untream)	hypertension	(96)

Association with disease is not known.