. 2016 Feb 22;9:845–853. doi: 10.2147/OTT.S95511

Table 1.

The characteristics of the studies

First author	Year	Study years	Country	Study design	Treatment for two groups		Number of patients		Stage	PFS (HR and 95% CI)	OS (HR and 95% CI)	Subgroup (number of patients)
First author	Year	Study years	Country	Study design	Surgery group	Definitive RT group	Surgery group	Definitive RT group	Stage	PFS (HR and 95% CI)	OS (HR and 95% CI)	Subgroup (number of patients)
Albain et al²¹	2009	1994–2001	USA and Canada	RCT (INT 0139)	Neo concurrent CRT + surgery	Neo concurrent CRT + definitive RT	202	194	T1–3N2M0	0.77 (0.62–0.96)	Total: 0.87 (0.70–1.10); L vs CRT: 0.66 (0.46–0.94) P vs CRT: 1.12 (0.70–1.79)	L vs CRT (90 vs 90); P vs CRT (51 vs 51)
van Meerbeeck et al²⁰	2007	1994–2002	the Netherlands	RCT (EORTC 08941)	Neo chemo + surgery	Neo chemo + definitive RT	167	165	T1–T3N2M0	1.06 (0.85–1.33)	1.06 (0.84–1.35)
Johnstone et al¹⁹	2002	1990–1994	USA	RCT	Neo chemo + surgery	Neo chemo + definitive RT	29	15	T1–T3N2M0	NR	0.81 (0.46–1.42)
Shepherd et al¹⁷	1998	NR	Canada	RCT	Neo chemo + surgery	Definitive RT	15	16	T1–T3N2M0	NR	0.49 (0.07–3.32)
Stephens et al²²	2005	1995–1999	England	RCT	Neo chemo + surgery	Definitive RT	24	24	T3N1M0/T1–3N2M0	NR	0.91 (0.49–1.72)
Koshy et al⁷	2013	1998–2004	USA	Retrospective	Neo CRT + surgery	Definitive RT	752	9,857	T1–T3N2M0	NR	L vs CRT: 0.51 (0.45–0.58) P vs CRT: 0.77 (0.63–0.95)	L vs CRT (564 vs 9,857); P vs CRT (188 vs 9,857)
Aggarwal et al⁸	2014	2000–2008	USA	Retrospective	Neo CRT + surgery	Definitive RT	155	103	T3N1M0/T1–3N2M0	NR	L vs CRT: 0.57 (0.45–0.58); P vs CRT: 0.77 (0.63–0.95)	L vs CRT (105 vs 103); P vs CRT (41 vs 103)
Darling et al⁹	2015	1997–2007	Canada	Retrospective	Neo CRT or chemo + surgery	Definitive CRT	104	111	T1–T3N2M0	NR	Total: 0.45 (0.33–0.62) L vs CRT: 0.48 (0.29–0.80)	L vs CRT (28 vs 34)
Bosch-Barrera et al¹⁸	2012	1996–2006	Spain	Retrospective	Neo chemo + surgery	Neo chemo + definitive RT	38	34	T1–T4N2M0	1.14 (0.61–2.15)	0.71 (0.38–1.32)

Abbreviations: Chemo, chemotherapy; CI, confidence interval; CRT, chemoradiation; HR, hazard ratio; L, lobectomy; Neo, neoadjuvant; NR, not reported; OS, overall survival; P, pneumonectomy; PFS, progression-free survival; RCT, randomized controlled trial; RT, radiotherapy.