Figure 5.
pH dependent drug release and cell viability of dox-loaded PIC (C/A ratio: 8).
Notes: (A) Dox release behavior of PIC (C/A ratio: 8) at different pH: 9.0 (●), 7.4 (○), 6.0 (□), and 4.0 (■); (B) cell viability of MCF-7 cells treated with dox-loaded PIC (C/A ratio: 8) at pH 7.4 (●) and pH 6.0 (■) after incubation for 48 hours.
Abbreviations: PIC, polyelectrolyte ionomer complex; C/A ratio, ratio of cationic PEI and anionic P(Asp) block; P(Asp), poly(aspartic acid); dox, doxorubicin.