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. 2016 Feb 3;13(3):2864–2870. doi: 10.3892/mmr.2016.4855

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Trx1 knockdown suppresses 2-Cys Prdxs expression. (A) Prdx1, (B) Prdx2, (C) Prdx3 and (D) Prdx4 were determined by reverse-transcription quantitative polymerase chain reaction. Prdx1-4 mRNA expression increased following OGD/R, which was inhibited by Trx1 knockdown. Values are expressed as the mean ± standard error of the mean (n=4). ^*P<0.05, ^**P<0.01 vs. the controls; ^#P<0.05, ^##P<0.01 vs. the si-Trx1 group. Trx1, thioredoxin 1; si, small interfering; OGD/R, oxygen glucose deprivation/reperfusion; Prdx, peroxiredoxin.